Operation Description
Sperm FISH (Fluorescence In Situ Hybridization) is an advanced genetic analysis method used to detect chromosomal abnormalities in sperm cells. It plays a significant role in detecting chromosomal aneuploidies (missing or extra chromosomes), particularly in men with low sperm count, low motility, and morphological abnormalities.
How Is It Different from Standard Tests?
In most cases, genetic blood tests (karyotype analysis) may be completely normal in men with poor sperm quality. However, this does not necessarily mean that the genetic makeup of the sperm cells is normal.
Sperm FISH tests directly examine sperm cells and most commonly detect aneuploidies for the following chromosomes:
• 13, 18, and 21 (autosomal chromosomes)
• X and Y (sex chromosomes)
This test provides important information, particularly in cases of recurrent IVF failures, miscarriages, and serious sperm problems such as azoospermia or oligoasthenospermia.
When is it Recommended?
• Unexplained infertility
• Recurrent early pregnancy losses
• Fertilization failure in IVF
• Severe sperm count/morphology disorders
• Couples with previous embryos with genetic problems
• Older fathers
Factors that Cause Chromosomal Disorders
Some environmental and lifestyle factors that can cause genetic disorders in sperm include:
• Excessive alcohol and smoking
• Obesity and poor nutrition
• High caffeine consumption
• Radiation or toxin exposure
• Chronic diseases and certain medications
What to Do If a High Aneuploidy Rate is Detected?
If a high rate of chromosomal disorders is detected in sperm during the FISH test:
• Cause-specific lifestyle changes
• Antioxidant treatments that reduce oxidative stress
• Repeat testing after an appropriate treatment period
• If necessary, approaches such as embryo genetic diagnosis (PGT-A) may be planned.
Sperm FISH Testing at Momart IVF Center
At Momart IVF Center, the FISH test is performed to international quality standards, and the results are interpreted with expert genetic counseling. The couple's entire clinical history is evaluated, and a personalized treatment strategy is determined.