Genetic testing in IVF treatments is not applied to every patient; it is only performed on specific couples based on particular medical reasons.
Genetic analyses aim to increase the chances of a healthy pregnancy and birth by detecting genetic disorders in embryos. However, genetic testing is not necessary in every IVF procedure. These tests are planned according to clinical needs, and the type of test performed varies depending on the patient's needs.
Types of Genetic Tests
Genetic tests applied to embryos during the in-vitro fertilization process are divided into three main groups:
- PGT-A (Preimplantation Genetic Screening):This involves screening embryos for numerical chromosome abnormalities (aneuploidies). It is particularly preferred in cases of advanced age, recurrent failure, and miscarriage.
- PGT-M (Single Gene Disease Test):It investigates whether genetic diseases known to be carried by the couple are passed on to the embryo. It is applied in couples who are related by marriage and in families with a history of genetic diseases.
- PGT-SR (Chromosomal Abnormalities Test):This procedure is performed when one of the parents has a structural chromosomal abnormality (e.g., translocation).
Each type of test has different planning, preparation, and result-taking processes. Therefore, the term "genetic testing" is actually a general expression encompassing different tests that serve multiple techniques and purposes.
In what situations are genetic tests performed on embryos?
Genetic testing may be recommended in the following situations:
🔹 consanguineous marriage couples who are co-carriers for rare genetic diseases
🔹 Child, pregnancy, or family history of genetic diseases individuals found
🔹 In women and/or men known chromosomal disorder detection
🔹 Advanced female age (>40 years old)
🔹 Previously unsuccessful IVF attempts living couples
🔹 Recurrent miscarriages women who passed
🔹 HLA compliant sibling couples who are planning a birth and have a sick child
What is the success rate of genetically healthy (euploid) embryo transfer?
Scientific data shows that in women with a normal uterine structure and good health a single genetically normal embryo (euploid embryo) pregnancy rate with transfer is approximately %70 This shows that.
This rate remains constant in subsequent transfers even if pregnancy does not occur on the first attempt; the pregnancy rate after transferring 3 normal embryos is... %95’e, In 5 transfers, however... %98’e It rises to that level.
Why Genetic Testing?
✅ It increases the likelihood of a healthy birth.
✅ It helps prevent recurrent miscarriages.
✅ It provides a more effective treatment process in terms of time and cost.
✅ It bases embryo selection on scientific principles.
✅ It increases pregnancy success.
In conclusion…
Genetic testing of embryos is a crucial tool in increasing the success rate of personalized IVF treatments. The appropriateness of each test, when it should be performed, and who should undergo it is assessed by our expert physicians based on patient history, genetic risks, and previous treatment experiences.