Sperm FISH (Fluorescent In Situ Hybridization) test examines sperm cells. chromosomal abnormalities It is an advanced genetic analysis method used to detect these conditions, particularly in men with low sperm count, low motility, and morphological abnormalities. chromosomal aneuploidies It plays an important role in detecting (missing or extra chromosomes).
What is the difference from standard tests?
Often, genetic tests (karyotype analysis) performed on blood samples from men with poor sperm quality may be completely normal. However, this does not mean that the genetic structure of the sperm cells is also normal.
Sperm FISH test, It directly examines sperm cells and most commonly searches for aneuploidies in terms of the following chromosomes:
- 13, 18, 21 (autosomal chromosomes)
- X and Y (sex chromosomes)
This test, in particular in recurrent IVF failures, lows, azoospermia or oligoasthenospermia Important information is obtained regarding serious sperm problems such as these.
In what situations is it recommended?
- Unexplained infertility
- Recurrent early pregnancy losses
- Fertilization failure in IVF treatment
- Severe sperm count/morphology abnormalities
- Couples who have previously had embryos with genetic problems
- Older prospective fathers
Factors that Cause Chromosomal Disorders
Some environmental and lifestyle factors that can cause genetic abnormalities in sperm include:
- Excessive alcohol and tobacco use
- Obesity and malnutrition
- High caffeine consumption
- Radiation or toxin exposure
- Chronic illnesses and certain medications
What to do if a high aneuploidy rate is detected?
If a high percentage of chromosomal abnormalities are detected in sperm during a FISH test:
- Cause-based lifestyle adjustments
- Antioxidant treatments that reduce oxidative stress
- Repeat the test after the appropriate treatment period.
- In necessary situationsembryo genetic diagnosis (PGT-A) Approaches such as these can be planned.
Sperm FISH Test at Momart IVF Center
At Momart IVF Center, FISH tests are performed according to international quality standards, and the results are interpreted with the assistance of expert genetic counselors. The treatment strategy is determined individually, taking into account the couple's entire clinical history.