Genetic mutations associated with blood clotting., This can affect the embryo's chances of implantation in the uterus and the continuation of the pregnancy. Therefore, it plays an important role in the evaluation of infertility and recurrent pregnancy loss.
Most Common Genetic Mutations
Factor V Leiden Mutation: It increases the risk of blood clots.
Prothrombin Gene Mutation (G20210A): It increases prothrombin levels.
MTHFR Mutation: It can affect folate metabolism, leading to clotting problems.
How do blood clotting disorders affect pregnancy?
New blood vessel formation is necessary for the embryo to implant in the uterus. A tendency towards blood clotting can disrupt this process.
It can lead to complications such as miscarriage, preeclampsia, placental problems, and fetal growth restriction.
Therefore, pregnancies in women with clotting disorders should be monitored more closely.
How is the diagnosis made?
Family history, patient history, and especially recurrent miscarriages are key factors in diagnosis. In suspected cases:
Factor II and V Leiden mutation tests
Screening for Antiphospholipid Antibody Syndrome (APAS) can be performed.
Treatment Methods
Blood-thinning medications (such as aspirin or heparin) can reduce the risk of miscarriage.
More frequent ultrasound and laboratory checkups are recommended throughout pregnancy.
Treatment plans must be tailored to each individual.
Antiphospholipid Antibody Syndrome (APAS)
This non-genetic condition is a significant cause of recurrent miscarriages.
Lupus is diagnosed with anticoagulant, anticardiolipin, and anti-β2 glycoprotein tests.
It can lead to serious complications in both in-vitro fertilization and natural pregnancy.
Treatment involves low-dose aspirin and blood-thinning injections.
What does the scientific literature say?
Some studies suggest that coagulation tests and treatments can improve pregnancy success.
Some people, however, say there is no noticeable difference.
Official guidelines generally recommend these tests be performed after two or more miscarriages.
However, since every miscarriage is a serious trauma for the couple, doctors often prefer to evaluate the condition earlier.
✨ Conclusion:
Clotting disorders are not always the cause of infertility, but they can negatively affect the chances of pregnancy in some couples. Therefore, personalized screening and treatment plans are of great importance, especially in cases of recurrent miscarriages or failed IVF treatments.
